|Amino Acid / Protein|| Glutamine
| ||Fresh cabbage juice has for a long time been used successfully against ulcers, probably due to its glutamine content. The amino acid glutamine works over time in doses as low as 500mg tid to heal stomach and small intestine lesions. A study of ulcers found that 1600mg of glutamine per day had a 50% cure rate within 2 weeks and 92% within 4 weeks.|
Propolis / Bee Products
| ||An extensive article on the use of Manuka Honey can be viewedhere.|
| ||Robert's Formula is a time-honored herbal preparation for upper GI inflammation. It sometimes contains bismuth, which kills H. Pylori, usually found in upper GI ulceration, as well as other microorganisms.|
| ||Mastic gum has killed H. Pylori and cured peptic ulcers after just 2 weeks of use.|
Licorice Root (Glycyrrhiza glabra)
| ||Licorice root, particularly deglycyrrhized licorice, can be a useful adjunct to antibiotic treatment because it accelerates the healing of the stomach lining. Deglycyrrhized licorice root (DGL) and glutamine have been used to get people off of antacids, H2 blockers and proton pump inhibiters (PPI). A typical dose of DGL will be 500mg tid either with or without a meal.|
In a study of DGL in gastric ulcers, 33 gastric ulcer patients were treated with either DGL (760mg TID) or a placebo for one month. There was a significantly greater reduction in ulcer size in the DGL group (78%), than in the placebo group (34%). Complete healing occurred in 44% of those receiving DGL, but in only 6% of the placebo group. [Gut 1969:10; pp.299-303]
Comfrey (Symphytum officionale)
Chlorella / Algae Products
Increased Water Consumption
| ||Consuming up to 12 cups of water per day can eliminate the helicobacter infection when present.|
| ||No proven relationship exists between peptic ulcer disease and the intake of alcohol. However, since alcohol can cause gastritis, moderation in alcohol consumption is often recommended.|
| ||Since coffee stimulates gastric acid secretion, moderation in coffee consumption is often recommended.|
| ||In an extensive study of the effect of bromelain on the stomach lining, it was found that bromelain increased the uptake of sulfur by 50% and glucosamine by 30-90%. Increased uptake of these substances allows the tissue to heal more rapidly. [Hawaii Med J 1976;2: pp.39-47]|
| ||Please see the link between H. Pylori and Antibiotics.|
| ||Prostaglandins are substances that are important in helping the gut linings resist corrosive acid damage. NSAIDs cause ulcers by interfering with prostaglandins in the stomach. However, those who use NSAIDs may have a special need for supplemental glutamine. Fortunately, sufficient glutamine can undo the damage caused by NSAIDs, maintaining permeability at a healthy level. For heavy NSAID users, supplementing with glutamine can spell the difference between healthy gastrointestinal tract versus ulcers and the "leaky gut syndrome." If you have symptoms that could be from stomach or peptic ulcers, NSAIDs should be avoided until these conditions are ruled out.|
| ||Cigarette smoking not only causes ulcer formation, but also increases the risk of ulcer complications such as bleeding, stomach obstruction and perforation. Cigarette smoking is also a leading cause of ulcer medication treatment failure: smoking slows the healing of ulcers.|
| ||Active men had one-half to one-third the risk of developing a duodenal ulcer over 20 years compared with their sedentary counterparts. Men who walked or ran at least 10 miles per week were 62% less likely than inactive subjects to develop an ulcer. Men who walked or ran less than 10 miles each week had about half the ulcer risk of those with no regular exercise.|
Test for Helicobacter Pylori Infection
Test for Occult Blood
| ||In a double-blind study on 18 patients, those taking zinc sulfate supplements had a gastric ulcer healing rate three times that of patients treated with a placebo. [The healing of gastric ulcers by zinc sulfate. Med J Aust 2(21): pp.793-6, 1975]|
But, Zinc Carnosine is much better.
Nutraceutical Therapy for Ulcers (and Gastritis). Excerpted from Holistic Primary Care, a Summer 2004 Special Report published by Metagenics. The report in its entirety may be viewed at www.needs.com
Zinc carnosine, a patented combination of two nutrients that have beneficial effects on the gastrointestinal mucosa, represents an important advance in the management of peptic ulcers. Widely used in Japan, where it is recognized as a drug by regulatory authorities, zinc carnosine given alone was shown by endoscope to resolve ulcers by 60 to 70%, a result comparable to conventional drug therapies and with a safety profile as good as or better than commonly used pharmaceuticals.
This novel compound contributes to ulcer healing through a number of different mechanisms, including the inhibition of Helicobacter pylori (H. pylori) - a bacterial strain thought to be causative of ulcers. Zinc carnosine has been shown to promote wound healing, reduce inflammation, improve secretion of the protective mucosal lining, and possess antioxidant effects. It can be used as a natural therapy, an antibiotic, or an alternative to conventional pharmaceuticals, such as proton pump inhibitors (i.e., Nexium) and H2 receptor antagonists (i.e., Pepcid), both of which serve to decrease hydrochloric acid (HCl). It can also be used as adjunctive therapy in combination with conventional ulcer drugs. Moreover, patients can safely take zinc carnosine with non-steroidal anti inflammatory drugs (NSAIDs) as a way of preempting their adverse gastric effects.
In many ways, zinc carnosine is an ideal complementary therapy for ulcers. Conventional allopathic medicines are suppressive and address the problem of peptic ulcers by controlling the corrosive aspects of stomach function (i.e., reducing acid secretion and eliminating H. pylori). Zinc carnosine enhances and strengthens the stomach's natural defensive and self-protective capacities. It thus provides benefits characteristic of natural products and holistic strategies by treating the cause of the problem, but with the strong scientific pedigree of a pharmaceutical.
WHAT IS ZINC CARNOSINE?
Elemental zinc is known to speed healing of mucosal wounds and damaged cells, particularly in the gut. Carnosine is a naturally-occurring dipeptide, comprised of the amino acids, beta-alanine and L-histidine. It is a strong free-radical scavenger capable of blocking free radical chain reactions, inhibiting cell damage. It is also essential for DNA and RNA polymerase activity to aid cell damage.
Zinc carnosine was developed in an effort to provide a therapy that bolsters the ability of the gastric lining to repair and protect itself. A chelate of elemental zinc and carnosine in a 1:1 ratio, zinc carnosine entered the Japanese market as a pharmaceutical for ulcer treatment in the early 1990s and has been marketed there under the trade name Polaprezinc.
GASTRIC MUCOSAL BALANCE: A NEW WAY OF THINKING ABOUT ULCER DISEASE
The digestive tract has a curious challenge. It must produce caustic matter (stomach acid, pepsin, enzymes, bile) capable of breaking down many different substances, including animal tissue much like those comprising the digestive organs themselves. Consequently, the mucosa must produce sufficient quantities of mucus and other protective factors to keep digestive juices from going to work on its own walls. Digestive health hinges on the balance between secretions of digestive substances and maintenance of the mucosal wall.
Peptic ulcers are best understood as the net result of an imbalance between the caustic processes of digestion and stomach-wall maintenance. When the latter can't keep up with the former, the stage is set for stomach-wall disruption and ultimately ulceration.
And even with the best pharmacotherapy, ulcer recurrences are common, suggesting that acid suppression and eradication of microbial pathogens are insufficient.
Hyper-secretion of stomach acid may play a role in some cases and this is clearly stress-related. However, under-secretion of mucus and/or a breakdown in stomach cell repair mechanisms likely play an equal, if not more significant, role. The current therapeutic challenge is to restore the delicate balance by addressing the factors that impair healing of the gastric lining and improve mucosal integrity.
CONVENTIONAL PHARMACOTHERAPIES AND THEIR LIMITATIONS
Pharmacologic treatment of ulcer disease is big business. Aside from costs, long-term treatment with acid-suppressing drugs can result in a number of untoward effects, many of which run counter to the primary objective of restoring digestive health.
Effective digestion is based upon maintaining strongly acidic pH in the stomach and a base pH in the intestines.Many people with heartburn and indigestion actually tend to have too little gastric acid, rather than too much, a condition especially common among the elderly. Thus, many older individuals with ulcers are already acidsuppressed before being given acid-suppressing drugs.
Further suppression via pharmacotherapy has downstream consequences, including poor digestion, malabsorption, and gradually deteriorating nutritional status. Acidsuppression therapy also reduces the secretion of gastric mucus, a natural response to reduced stomach acidity. However, when a patient discontinues acid suppression drugs and returns to normal acid secretion levels, the gastric lining is left even more vulnerable than it was initially. This accounts for the high recurrence rate following treatment cessation.
Bear in mind that stomach acid is among the body's primary defense strategies, providing a way to destroy pathogens ingested with food. By reducing HCl, suppressive therapies increase the possibility that pathogenic organisms will be able to pass through the gastric phase and colonize the lower GI tract.When stomach acid production is deficient and gastric digestion incomplete, it is more difficult to maintain a healthy intestinal ecology. Similarly, antibiotics that kill off H. pylori knock off a lot of friendly flora as well, increasing the chances of intestinal overgrowth with pathogenic bacteria or yeasts. Plus, gastric acid triggers the release of enzymes in the small intestine, and reducing this stimulus results in an inadequate release of digestive juices.
In rats subjected to aspirin-induced gastric mucosal injury, zinc carnosine markedly reduced lipid peroxidation, neutrophil accumulations, and inflammatory factors. The net result was significant reduction in mucosal erosions. A separate study, also in rats, showed that zinc carnosine could prevent the reduction in gastric mucus secretion that follows the exposure to alcohol, another ulcer trigger.
CLINICAL TRIALS: SAFE AND EFFECTIVE MONOTHERAPY
To date, there have been eight clinical trials of zinc carnosine for the treatment of peptic ulcers. Initial dose-ranging and safety studies evaluated doses of 75 to 600 mg per day, given under fasting conditions, as well as at meal times. The data indicate that zinc carnosine is entirely safe up to 600 mg per day. The only adverse effects were mild heartburn-like symptoms in two patients on the highest dose taken without food. There was no toxic accumulation of zinc in the lood, and the compound was readily excreted in urine and stool without adverse kidney or lower GI effects. Researchers demonstrate zinc carnosine to be highly effective when used continuously for 8 weeks. A fitting recommendation is one tablet, twice a day, of Zinlori 75 from Metagenics Inc. Beyond its applications in the management of peptic ulcers, zinc carnosine may have a role in treatment of gastritis and stomatitis.
Oxygen / Oxidative Therapies
Ozone / Oxidative Therapy
| ||Cuban doctors are using capsules filled with ozonated oil to treat gastroduodenal ulcers, gastritis, giardia and peptic ulcers.|
Vitamin B3 (Niacin)
| ||In rare cases, niacin has aggravated peptic ulceration.|| |