The Analyst™

Comprehensive diagnosis of your symptoms


  Low Pregnenolone Level  
Search treatments and conditions
Signs, symptoms and indicators | Conditions that suggest it | Contributing risk factors | Recommendations


Pregnenolone is a hormone with its own actions, as well as being a mother hormone for sex and adrenal hormones. It is available over the counter although caution is advised with regard to hormone use. This hormone's level can be determined in the laboratory but it is an uncommon test. Many naturopaths will test for it and other hormones with a urine sample. Estrogen-deficient women often are low in pregnenolone, an essential hormone (derived from cholesterol) which is a precursor to progesterone. Pregnenolone may be a significant contributing factor in depression. Pregnenolone is abundant in the brain where it improves the transmission of nerve impulses and facilitates communication between brain cells. In a sense, people who are depressed may have poor communication, neuronally speaking, between the different parts of their brain because they are deficient in pregnenolone. This hormone appears to have a great calming effect because it activates receptor sites in brain cells for GABA (itself a calming agent), enabling more GABA to be absorbed by the cells.


Signs, symptoms & indicators of Low Pregnenolone Level:
Symptoms - Metabolic  Low stamina

Symptoms - Mind - Emotional


Symptoms - Mind - General

  Short-term memory failure

Conditions that suggest Low Pregnenolone Level:
Lab Values  Low Total Cholesterol


 A study found that depressed patients generally had low levels of pregnenolone. [Biological Psychiatry, 35(10): pp.775-80, 1994]



Risk factors for Low Pregnenolone Level:
Supplements and Medications  (Past) cholesterol-lowering drug use

Symptoms - Mind - General

  Absence of short-term memory loss

Symptoms - Nervous

  (Severe) spinal cord injury

Recommendations for Low Pregnenolone Level:
Hormone  Pregnenolone

Lab Tests/Rule-Outs

  Test / Monitor Hormone levels

Weak or unproven link
Strong or generally accepted link
Strongly counter-indicative
Highly recommended