Some medical and veterinary doctors have been pioneering the use of microdose DNA from natural sources for a variety of respiratory health conditions. The modality has been used to treat respiratory ailments in dogs, cats and horses, as well as in infants, children, and adults. The observations from a number of these doctors also indicate that we are entering a new area of natural microdose DNA-based therapeutics.
The use of this natural microdose DNA comes as a surprise in that the clinical effect is impressive, and yet the therapeutic agent is used in the LOW microgram level. This is reminiscent of both homeopathy, where very low dose agents are used, and low dose neutralization therapy, which is often used for allergies and hypersensitivities.
Dr. Albert Dahlberg, M.D., Ph.D. , a professor at Brown University, says that natural microdose DNA is different than other DNA-based therapies. “This approach does not affect gene transfer; it relies on the physical molecule itself to place into motion a series of events at the cellular level”.
Dr. Dahlberg has determined that the nucleotide sequence doesn’t matter. Different animal sources of DNA were tested and found to work the same. Dr. Dahlberg created synthetic DNA with only adenine and thymine and it also appeared to produce the same results. So in opposition to the stated supposition of the published work, DNA can provide a general signal which may be related to the component nucleotides, but not necessarily their sequence.
This is not to detract from the impressive body of work published by many scientists in dozens of publications. And we do not suggest that nonspecific microdose DNA application is the same as the heavily researched bacterial sequence DNA. However, there appear to be striking similarities.
The microdose DNA appears to stimulate P2Y receptors on epithelial cells that line the respiratory tract and ear canal. P2Y stimulation then causes the cilia to beat faster and stronger, which in turn enhances mucus movement leading to drainage, expectoration, etc., and thus altering, or disrupting that habitat so favored by infectious agents. That is to say, DNA may likely have no direct antibacterial or antiviral effect, but rather, have a direct action on mucus itself in that those agents no longer find the ear canal or respiratory tract to be favorable habitats.
There is a DNA microdose product available now called Mucolyxir from Allergy Research Group. Mucolyxir™ is a DNA-based nutritional supplement, utilizing DNA from salmon. One method by which the body attempts to keep the lungs clear of mucus is to mount an immune response against the agent(s) causing the problem. When the attempts to eliminate foreign material fail, excessive DNA can build up from lysed white blood cells, resulting in viscous mucus. The small amount of DNA in Mucolyxir™ may balance mucus levels via a neutralization or feedback mechanism, just as a bit of ragweed extract is used to balance immune response to environmental factors. Based on pre-clinical investigations and clinical trials, Mucolyxir™ appears to support cilia motion, and liquification and elimination of mucoid substance.
What is particularly surprising is that a single dose ‘fits all’, and not only in humans. From interviews of doctors using natural microdose DNA, the same general dosages a few times a day works for kittens, puppies and horses, as well as for infants, children, and adults. So there is apparently quite a large range of dosages from which these benefits may generate. Increasing the dosage does make a difference to some in terms of achieving greater benefit. For others, the process may be too fast and they reduce the number of drops accordingly.
Dosage: 1 or 2 drops, placed in mouth slowly then swallowed, one to four times per day. To avoid dilution, do not eat or drink for 5 minutes after taking. Additional Usage Notes: Day 1: Take 1 drop every fifteen minutes for one hour. Then take 1 drop every hour until bedtime. Days 2 and 3: Take 1 drop after each meal and before bed (4 times total). Day 4 and beyond: Maintain schedule or use only as needed.
Microdose DNA can help with the following
Ear Infection, Middle
Microdose DNA was especially valuable in acute and chronic otitis media. Obstruction is often the pre-requisite of infection, so it should have come as no surprise to us that microdose DNA would also excel in otitis media. In clinical trials with over 100 infants and children with acute otitis media, what we found is that 80-90% of these children respond on microdose DNA.[Allan Lieberman, MD – Natural Microdose DNA AAEM Presentation, October 2004, Hilton Head, South Carolina]
Sinusitis
Microdose DNA was especially valuable in acute and chronic sinusitis. Patients with chronic sinusitis would refuse literally to come off the microdose DNA once we had put them on it because they felt so much better. [Allan Lieberman, MD – Natural Microdose DNA AAEM Presentation, October 2004, Hilton Head, South Carolina]
Cystic Fibrosis
Allan Lieberman, M.D. has reported the following:
“We went out and found two or three sources of DNA and we tried it. I was fortunate enough to have twins, in their mid-twenties who had cystic fibrosis that volunteered to try these DNA drops sublingually and … it really worked. It had incredible expectorant action, the mucus just kept coming up so incredibly thin that we had to learn very quickly to be careful that we don’t drown these patients. They improved their pulmonary function. They gained weight for the first time in years, so much so that they had to go out and buy new clothes to fit their new bodies, and they did not have to be hospitalized for the first time in years because of their disease.
So based upon this initial study, we went out and looked for other cystic fibrosis patients. Over time, we accumulated enough cases for a pilot study to see that what we were doing was really working.” [Natural Microdose DNA AAEM Presentation, October 2004, Hilton Head, South Carolina]
COPD (Chronic Obstructive Pulmonary Disease)
“We looked at the COPD patients characterized by dry cough, little or no sputum production, and severely impaired pulmonary function, where their forced expiratory volume was in the vicinity of about 25% and with evidence of non-reversible disease. The microdose DNA demonstrated increased sputum production with improvement in COPD symptoms, especially shortness of breath. There was obvious improvement in forced expiratory volume, and also in the carbon monoxide coefficient of diffusion. There was significant increase in distance traveled during 6 minute walks, and a corresponding increase in their oxygenation, and again, with an excellent safety profile.” [Allan Lieberman, MD – Natural Microdose DNA AAEM Presentation, October 2004, Hilton Head, South Carolina]
Bronchitis, Acute
In the microdose DNA bronchitis study, the summary was: In patients with wet cough, sputum production, and impaired pulmonary function, which was a measure of forced expiratory volume in one second of about 65%, the DNA demonstrated increased sputum production and ease of expectoration. There was a very definite improvement in the symptoms of chronic bronchitis including ease of breathing. People were able to sleep through the night without coughing. There was significant improvement with walking and working. Objectively, there was improved pulmonary function, most notably on small airway flow, the FEV 25/75 fraction and by improved overall quality of life. The more important thing about this was it’s excellent safety profile. There was no question that there was a very statistically significant difference between the active and placebo groups.[Allan Lieberman, MD – Natural Microdose DNA AAEM Presentation, October 2004, Hilton Head, South Carolina]
Key
| May do some good |
| Likely to help |
| Highly recommended |
Glossary
DNA
Deoxyribonucleic acid, the large molecule that is the main carrier of genetic information in cells. DNA is found mainly in the chromosomes of cells.
Microgram
(mcg): 1/1,000 of a milligram in weight.
Homeopathy
A system of medicine based on the belief that the cure of disease can be effected by minute doses of substances that, if given to a healthy person in large doses, would produce the same symptoms as are present in the disease being treated. Homeopathy employs natural substances in small doses to stimulate the body's reactive process to remove toxic waste and bring the body back into balance.
Allergy
Hypersensitivity caused by exposure to a particular antigen (allergen), resulting in an increased reactivity to that antigen on subsequent exposure, sometimes with harmful immunologic consequences.
pH
A measure of an environment's acidity or alkalinity. The more acidic the solution, the lower the pH. For example, a pH of 1 is very acidic; a pH of 7 is neutral; a pH of 14 is very alkaline.
White Blood Cell
(WBC): A blood cell that does not contain hemoglobin: a blood corpuscle responsible for maintaining the body's immune surveillance system against invasion by foreign substances such as viruses or bacteria. White cells become specifically programmed against foreign invaders and work to inactivate and rid the body of a foreign substance. Also known as a leukocyte.