|Animal-based|| Shark Liver Oil
| ||See the link between Low White Count and Shark Liver Oil.|
| ||In China, primary ITP is the main subject of reports suggesting that Chinese herbs - but not acupuncture - will raise the platelet levels in patients with persistent ITP, often to an acceptable level although only rarely to the normal range. According to the clinical reports, the use of herbs will often raise the platelets from the unacceptable level (below 50, at which bleeding that is difficult to stop may occur) to an average of about 75-85. Normal platelet levels are usually defined as 150 or above. Some patients described in the literature had their platelet levels reach over 100 and a small number attained a completely normal level.|
A Chinese formula used for IDP contained: astragalus, codonopsis, tang-kuei, moutan, agrimony, isatis leaf, perilla stem, licorice, raw rehmannia, cooked rehmannia and eclipta. The trial group of 36 patients receiving this formula ranged in age from 13-60 years. Treatment time was at least three months and it was reported that all but 3 of the patients had improvement of symptoms. The average increase of platelets was from 38 to 79, and the average decrease in IgG was from 74 to 32. [Shanghai Journal of Traditional Chinese Medicine 1991; (3): pp.1-3]
Chinese Thoroughwax (Bupleurum falcatum)
| ||A series of 10 cases comprised 5 males and 5 females were treated with Minor Decoction of Bupleurum for a low platelet count. The duration of the condition was 4-72 days, averaging 30 days. All cases manifested purpura in the skin and mucosa, with nose bleed in 7 cases, gingival hemorrhage in 4 cases and uterine bleeding in 2 cases.|
The classical Minor Decoction of Bupleurum consists of Radix Bupleuri, Radix Ginseng, Radix Codonopsis Pilosulae, Rhizoma Pinelliae, Radix Scutellariae, Radix Glycyrrhizae, Rhizoma Zingiberis Recens, and Fructus Ziziphi Jujubae. The authors modified the prescription by eliminating Rhizoma Pinelliae and Rhizoma Zingiberis Recens and adding Herba Equiseti Hiemalis 15gm, Herba Verbenae 15gm, and Radix Rehmanniae 15gr. For patients with severe hemorrhage, the mixture was administered once daily by intravenous drip. The mixture consisted on 5% glucose solution, 250-300 ml, dicynone 2.0 gm, adrenobazone 20 mg, vitamin K 8-12 mg, vitamin C 500 mg, and p-aminomehyl benzoic acid .3 gm. For cases with dripping uterine bleeding, pituitrin 5-10 IU was added. The intravenous medication was terminated when hemorrhage was alleviated. For anemia due to blood loss, ferreous agents were administered.
The duration of treatment was 14-44 days, averaging 28 days. Skin and mucosa hemorrhages stopped in all cases and the blood platelet count rose averaging 121. The therapeutic results were deemed markedly effective in 6 cases and fairly effective in one; the remaining 3 cases dropped out of follow-up.
Kelp / Seaweed
| ||It is noted that kelp can concentrate heavy metals, and that some kelp preparations contain substantial levels of arsenic. It has been noted that urinary arsenic excretion in patients with peripheral neuropathy, who have been taking kelp tablets, has increased, and seaweed ingestion has been linked with chronic thyroiditis. Arsenic intoxication can cause bone marrow depression and megaloblastic changes. Physicians need to be aware of the potential dangers of contaminants in some kelp preparations.[Severe Dyserythropoiesis and Autoimmune Thrombocytopenia Associated With Ingestion of Kelp Supplements, Pye, Kathryn G., et al, The Lancet, June 20, 1992;339:1540]|
Conventional Drugs / Information
| ||Attacking a platelet-depleting autoimmune disease in a whole new way, an experimental drug is helping patients with immune thrombocytopenic purpura (ITP) once again produce healthy amounts of platelets -- with no major side effects.|
That's the conclusion of a new, multicenter study led by Dr. James B. Bussel, professor of pediatrics at Weill Cornell Medical College, attending pediatrician at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, and director of the Hospital's Program for Platelet Disorders.
His team's findings appear in The New England Journal of Medicine, November 19, 2006.
The new drug, a novel protein called AMG 531, successfully boosted platelet production in patents with chronic ITP, a serious autoimmune disorder that affects more than 16,000 adult Americans, and perhaps as many children, each year.
| ||Five patients with thrombocytopenic purpura received 200-400mg of alpha-tocopherol acetate daily. Within 7-14 days, platelet counts and capillary fragility returned to normal or near normal. [Science 163: 762, 1946)] Note, however, that vitamin E is known to increase bleeding tendency by reducing platelet aggregation, so higher doses may be contraindicated for some patients.|| |