The Analyst™

Comprehensive diagnosis of your symptoms


  Enlarged Spleen  
Search treatments and conditions
Signs, symptoms and indicators | Conditions that suggest it | Contributing risk factors | Other conditions that may be present | Recommendations


The spleen is an organ that is a part of the lymph system. It filters the blood and maintains healthy red and white blood cells and platelets. The spleen may be affected by many conditions involving the blood or lymph system, and by infection, malignancies, liver disease, and parasites. It performs a wide variety of functions. The spleen may be enlarged without any symptoms being present. When present, symptoms of splenomegaly can include:

  • Inability to eat a large meal
  • Pain on the upper left side of the abdomen
  • Hiccups
In nearly 5% of individuals with enlarged spleens, no underlying cause can be determined.

Most individuals with splenomegaly require treatment for the underlying disease. Medications for underlying infections and possible radiation therapy are used as appropriate. The spleen is surgically removed (splenectomy) when medically necessary, when it is markedly enlarged, and when other treatments are not effective. A splenectomy may also be done to assess the rate of disease progress, called staging, if it is cancerous.


Signs, symptoms & indicators of Enlarged Spleen:
Symptoms - Cardiovascular  (Possibly) enlarged spleen

  Absence of enlarged spleen

Symptoms - Gas-Int - General


Conditions that suggest Enlarged Spleen:
Circulation  Anemia, Hemolytic

Risk factors for Enlarged Spleen:
Autoimmune  Sarcoidosis


 The spleen is an organ that helps your body fight infection and remove unwanted material. When a person has a thalassemia, the spleen has to work very hard. As a result, the spleen becomes larger than normal. This makes anemia worse. If the spleen becomes too large, it must be removed.

  Sickle Cell Trait / Disease


  Wilson's Disease


  Chronic / Hidden Infection
  CMV Infection
  Parasite Infection
  Epstein-Barr virus (EBV)


  Cystic Fibrosis

Organ Health

  Cirrhosis of the Liver
 Normally, blood from the intestines and spleen is carried to the liver through the portal vein. But cirrhosis slows the normal flow of blood, which increases the pressure in the portal vein. This condition is called portal hypertension. When portal hypertension occurs, the spleen frequently enlarges and holds white blood cells and platelets, reducing the numbers of these cells in the blood. A low platelet count may be the first evidence that a person has developed cirrhosis.


  Cancer / Risk - General Measures
  Increased Risk of Lymphoma

Tumors, Malignant

  Non-Hodgkin's Lymphoma
  Leukemia, Acute Lymphocytic (ALL)
  Leukemia, Acute Myelogenous (AML)
  Leukemia, Chronic Lymphocytic (CLL)
  Leukemia, Chronic Myelogenous (CML)

Enlarged Spleen suggests the following may be present:
Hormones  Wilson's Disease

Recommendations for Enlarged Spleen:
Surgery/Invasive  Surgery
 When an enlarged spleen causes serious complications or the underlying problem can not be identified or treated, surgical removal (splenectomy) may be an option. In chronic or critical cases, surgery may offer the best hope for recovery.

However, elective spleen removal requires careful consideration. While you can live an active life without a spleen, you are more likely to contract serious or even life-threatening infections, including an overwhelming post-splenectomy infection. Another treatment to consider is radiation. This can sometimes shrink the spleen so that surgery will not be needed.

Weak or unproven link
Strong or generally accepted link
Proven definite or direct link
Very strongly or absolutely counter-indicative
May do some good


Anemia:  A condition resulting from an unusually low number of red blood cells or too little hemoglobin in the red blood cells. The most common type is iron-deficiency anemia in which the red blood cells are reduced in size and number, and hemoglobin levels are low. Clinical symptoms include shortness of breath, lethargy and heart palpitations.

Cirrhosis:  A long-term disease in which the liver becomes covered with fiber-like tissue. This causes the liver tissue to break down and become filled with fat. All functions of the liver then decrease, including the production of glucose, processing drugs and alcohol, and vitamin absorption. Stomach and bowel function, and the making of hormones are also affected.

Hypertension:  High blood pressure. Hypertension increases the risk of heart attack, stroke, and kidney failure because it adds to the workload of the heart, causing it to enlarge and, over time, to weaken; in addition, it may damage the walls of the arteries.

Lymph:  A clear fluid that flows through lymph vessels and is collected from the tissues throughout the body. Its function is to nourish tissue cells and return waste matter to the bloodstream. The lymph system eventually connects with and adds to venous circulation.

Parasite:  An organism living in or on another organism.

Thalassemia:  The thalassemias are a diverse group of genetic blood diseases characterized by absent or decreased production of normal hemoglobin, resulting in a microcytic anemia of varying degree. The thalassemias have a distribution concomitant with areas where P. falciparum malaria is common.

White Blood Cell:  (WBC): A blood cell that does not contain hemoglobin: a blood corpuscle responsible for maintaining the body's immune surveillance system against invasion by foreign substances such as viruses or bacteria. White cells become specifically programmed against foreign invaders and work to inactivate and rid the body of a foreign substance. Also known as a leukocyte.