D-glucarate functions by inhibiting the dangerous beta-glucuronidase enzyme, thus protecting the critical �glucuronidation� detoxification mechanism. One example of the importance of glucuronidation can be seen in the risk factors for breast cancer. Excess levels of free estrogens and the beta-glucuronidase enzyme are associated with increased incidence of breast cancer. The beta-glucuronidase enzyme is associated with an increase in the number of estrogen receptors. D-glucarate has been shown to lower estrogen receptors while reducing tumor growth. When breast cells hyper-proliferate in response to excess estrogen stimulation, the risk of breast cancer increases. In men, excess estrogen stimulation in the prostate gland can result in benign enlargement. D-glucurate suppresses the �bad� enzyme beta-glucuronidase, thus helping to protect against the carcinogenic effects of estrogen. This discovery helps explain why those who eat certain types of vegetables and fruits have relatively low rates of cancer.