Gilbert’s Syndrome, characterized by a chronically elevated serum bilirubin level (1.2 to 3.0mg/dL), is the most common of all benign unconjugated hyper-bilirubinemias. Previously considered rare, this disorder is now known to affect as much as 5% of the general population. The condition is usually asymptomatic, although some patients do complain about anorexia, malaise, and fatigue. In a small study, the most common symptom was chocolate and sweet craving followed by fatigue.
Mild unconjugated hyperbilirubinemia is the only significant laboratory abnormality, which is important clinically because it is often misdiagnosed as chronic hepatitis. Research indicates that Gilbert’s syndrome is due to a slow down in the liver’s Phase II detoxification system. A 31% slower rate of glucuronidation has been reported in the typical person with Gilbert’s syndrome.