Premenstrual Syndrome PMS D (Depression)

This subgroup of PMS is the least prevalent and is relatively rare in its pure form. Its key symptom is depression.


Signs, symptoms & indicators of Premenstrual Syndrome PMS D (Depression)

Symptoms - Mind - Emotional  

Unexplained teariness/sadness


Depression with fatigue

Symptoms - Mind - General  

Short-term memory failure

Symptoms - Reproductive - Female Cycle  

Pre/menstrual depression

PMS type D is characterized chiefly by depression.


Poor concentration during cycle

Symptoms - Sleep  

Being a light sleeper


Unsound sleep


(Frequent) difficulty falling asleep

Conditions that suggest Premenstrual Syndrome PMS D (Depression)

Symptoms - Reproductive - Female Cycle  

Being/being post menopausal


Risk factors for Premenstrual Syndrome PMS D (Depression)

Symptoms - Mind - General  

Absence of short-term memory loss

Recommendations for Premenstrual Syndrome PMS D (Depression)

Amino Acid / Protein  



In patients with PMS Type D, progesterone levels may be elevated. You should have your hormone levels checked prior to any hormone therapy: using progesterone cream may only make symptoms worse.



Lead blocks the binding of estrogen to receptor sites and but has no effect on progesterone. A chronic magnesium deficiency may be a contributing factor as it results in increased lead absorption and retention, while decreasing resistance to stress. Hair mineral analysis has shown that, in general, PMS patients have higher heavy metal levels and lower magnesium levels than non-PMS controls. Menstrual cramps, irritability, fatigue, depression and water retention have been lessened with magnesium, usually given along with calcium and often with vitamin B6. Magnesium is often at its lowest level during menstruation. Supplementing magnesium in the same amount (or more) as calcium (about 500-1,000mg daily) is currently recommended for premenstrual problems.


Vitamin B6 (Pyridoxine)

In one study, women received 50mg per day of vitamin B6 or a placebo for 3 months. Symptoms amongst these women included depression, irritability, tiredness, headache, breast tenderness and swollen abdomen/hands. At this dose depression, irritability and tiredness were the only symptoms to respond and they were reduced by 50%. [Gynecol Obstet Invest 1997;43(2): 120-124]


Weak or unproven link
Strong or generally accepted link
Strongly counter-indicative
May do some good
Likely to help
Reasonably likely to cause problems


Premenstrual Syndrome

PMS consists of various physical and/or emotional symptoms that occur in the second half of the menstrual cycle, after ovulation. The symptoms begin about midcycle, are generally the most intense during the last seven days before menstruation and include: acne; backache; bloating; fatigue; headache; sore breasts; changes in sexual desire; depression; difficulty concentrating; difficulty handling stress; irritability; tearfulness.

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