The use of CoQ10 may be of benefit in several disorders. When supplementing with CoQ10, however, it is possible that a pre-existing CoQ10 deficiency may be necessary for any benefits to be seen. Measurement of plasma CoQ10 concentrations can assist in detecting deficiency states and thus serve as a dosage guide when oral supplementation is indicated.
Conditions that suggest Vitamin CoQ10 Need
Elevated Total Cholesterol
The statin drugs used to treat elevated blood cholesterol levels by blocking cholesterol synthesis also block CoQ10 synthesis. Supplemental CoQ10 should be considered in anyone on statin drugs.
Risk factors for Vitamin CoQ10 Need
(Past) cholesterol-lowering drug use
HMG-CoA reductase inhibitors (“statin” drugs) used to treat elevated blood cholesterol levels by blocking cholesterol synthesis also block CoQ10 synthesis. The resulting lowering of blood CoQ10 level is due to the partially shared biosynthetic pathway of CoQ10 and cholesterol. Statins deplete your body of CoQ10, which can have devastating results.
History/absence of CoQ10 use
Counter Indicators
CoQ10 use
Recommendations for Vitamin CoQ10 Need
Key
| Weak or unproven link |
| Strong or generally accepted link |
| Proven definite or direct link |
| Strongly counter-indicative |
| Highly recommended |
Glossary
Cholesterol
A waxy, fat-like substance manufactured in the liver and found in all tissues, it facilitates the transport and absorption of fatty acids. In foods, only animal products contain cholesterol. An excess of cholesterol in the bloodstream can contribute to the development of atherosclerosis.