Inositol hexaphosphate (IP6), also called phytic acid, in research since 1985 has inhibited the onset and progression of cancers in animals, but supportive research in humans is lacking. All research suggesting beneficial effects from taking IP-6 involve animals and not people. It is not known whether IP6 would be useful for the treatment of human disease or if so, what would be the optimal amount. IP6 is associated with dietary fiber and thus is naturally present in a wide variety of plant foods, especially wheat bran, whole grains, and legumes. The average dietary intake ranges from 1-1.5grams phytate per day.
Caution is advised when using IP6 supplementally for an extended period. Phytate in foods reduces mineral absorption, especially iron. Supplemental phytate (IP6) will further contribute to this potential problem. Additional mineral supplementation may be required.
When IP6 is recommended, the dose is 2-8grams daily, which should be taken on an empty stomach to avoid interaction with dietary proteins. Consider taking supplemental inositol with IP6 because additional unbound inositol multiplies its therapeutic activity.