GHB, a now illegal compound once sold in health food stores, was discovered in 1963 as a naturally occurring substance in the human brain (Nature 1963;200:1207-1208). Researchers have suggested that it acts as a neurotransmitter, but the mechanism of action producing the clinical effects is unknown. In the 1970s, GHB was used to treat sleep disorders, and some interest in this use continues. Some doctors feel it is the most reliable medication for inducing sleep that exists. It is thought to induce rapid eye movement sleep, decreasing symptoms of narcolepsy. Many prominent doctors have been outspoken about the unnecessary legal restrictions placed on this naturally occurring substance.
For a summary of the history and actions of GHB please visit our GHB Summary page.
Gamma-hydroxybutyrate Withdrawal Syndrome
A withdrawal syndrome following extreme chronic use of gamma-hydroxybutyrate (GHB) has been described in isolated case reports. All patients had been ingesting GHB frequently (every 1-3 hours) around the clock, for a period from 2 months to 3 years. Withdrawal symptoms began soon after cessation of GHB and lasted for 5-15 days. Early symptoms were mild (insomnia, tremors, nausea, vomiting, confusion) but progressed over several days to autonomic instability (tachycardia and hypertension), visual and auditory hallucinations, and delirium.